Disclaimer, I am not a health professional All information from any source should always be viewed under scrutiny

The TL;DR is, The wrist will bend upwards excessively with excessive max height or button height, causing excessive carpal tunnel pressure and increased risk of Carpal Tunnel Syndrome, needing to be reduced from the standard 38mm for hands below ~197mm.

Even if a mouse is theoretically small enough in maximum dimensions, grip width, the shape may not fit under your hand at rest and still cause problems.

The ability to have clicks as low as 20gf to reduce strain from repetitive clicking, and can be more suitable for smaller hands, may cause strain trying to avoid accidental clicks.

There is less risk of RSI if your hand is larger, due to the typically lowered extension while using a mouse of the same size.

Gathered data at bottom of Measurements to give you an idea, direct link to graphs, though I highly suggest reading the measurements page first.

The main health risks associated with mice are varieties of Repetitive Strain Injuries. (also known as Musculoskeletal Disorders)

The most common one is Carpal Tunnel Syndrome, caused by applying repetitive or sustained pressure to the Carpal Tunnel near the wrist;

Through excessive wrist extension and flexion, (bending the wrist up and down respectively) by applying direct force to the area, or through excessive thumb, index and middle finger extension and flexion.

If you have symptoms of tingling, loss of sensation, burning sensation, numbness or pain in either hand, consult a doctor.

For mice specifically, the worry is excessive height causing excessive wrist and finger extension.

This includes both max hump height and button height.

Though, any problems will be worsened if you have a poor seating situation.

10-20 degrees of flexion is where the carpal tunnel pressure is lowest, and so, optimal.