Holy Grail layout is a layout with a fixed height header and footer, and a center with 3 columns. The 3 columns include a fixed width sidenav, a fluid center, and a column for other content like ads (the fluid center appears first in the markup). CSS Flexbox can be used to achieve this with a very simple markup:

HTML Markup:

<div class="container">
  <header class="header">Header</header>
  <div class="content-body">
    <main class="content">Content</main>
    <nav class="sidenav">Nav</nav>
    <aside class="ads">Ads</aside>
  </div>
  <footer class="footer">Footer</footer>
</div>

CSS:

body {
  margin: 0;
  padding: 0;
}

.container {
  display: flex;
  flex-direction: column;
  height: 100vh;
}

.header {
  flex: 0 0 50px;
}

.content-body {
  flex: 1 1 auto;
  
  display: flex;
  flex-direction: row;
}

.content-body .content {
  flex: 1 1 auto;
  overflow: auto;
}

.content-body .sidenav {
  order: -1;
  flex: 0 0 100px;
  overflow: auto;
}

.content-body .ads {
  flex: 0 0 100px;
  overflow: auto;
}

.footer {
  flex: 0 0 50px;
}

Demo